The ability of exogenous heme to restore globin synthesis in reticulocytes with impaired heme formation

Abstract

The addition of isonicotinic acid hydrazide (INH) or cycloheximide decreases the incorporation of 75Se-methionine and 14C-labeled aminoacids into globin. 10 −4M hemin added to the incubation mixture removes the inhibition of globin synthesis caused by INH but is without effect on the synthesis of globin inhibited by cycloheximide.