Abstract
Abelson murine leukemia virus (A-MuLV) is an acute transforming retrovirus which induces a rapid lymphosarcoma in mice. The virus arose in one of a series of mice that were treated with prednisolone and infected with the replication-competent retrovirus Moloney murine leukemia virus (M-MuLV) (1, 2). One such mouse developed a non-thymic tumor; the cause was shown to be a virus when it was demonstrated that filtered extracts from this tumor were capable of inducing similar tumors in animals. These tumors were quite distinct from the thymic tumors normally induced by the parental M-MuLV, suggesting that a new virus had arisen in the course of the infection. This new virus, termed A-MuLV, has been the subject of intensive study in recent years. The analysis of the structure of the viral genome has had profound effects on our thinking about the mechanisms by which oncogenic gene structures can arise. This review will describe the biology of the virus, its genetic structure, current models for the origin of th...
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