Abstract
Pontin and Reptin are related partner proteins belonging to the AAA+ (ATPases Associated with various cellular Activities) family. They are implicated in multiple and seemingly unrelated processes encompassing the regulation of gene transcription, the remodeling of chromatin, DNA damage sensing and repair, and the assembly of protein and ribonucleoprotein complexes, among others. The 2nd International Workshop on Pontin and Reptin took place at the Instituto de Tecnologia Química e Biológica António Xavier in Oeiras, Portugal on October 10–12, 2014, and reported significant new advances on the mechanisms of action of these two AAA+ ATPases. The major points under discussion were related to the mechanisms through which these proteins regulate gene transcription, their roles as co-chaperones, and their involvement in pathophysiology, especially in cancer and ciliary biology and disease. Finally, they may become anticancer drug targets since small chemical inhibitors were shown to produce anti-tumor effects in animal models.
Highlights
Pontin and Reptin are related partner proteins belonging to the AAA+ (ATPases Associated with various cellular Activities) family
They were discussed during a First International Workshop held in Bordeaux, France, in 2012. It was a great success as it allowed scientists from various fields to meet for the first time, to discuss in depth their favorite proteins, and to share expertise and reagents. This Workshop led to a consensus in limiting the number of names used for these proteins to Pontin/RUVBL1 and Reptin/RUVBL2 in humans (Rosenbaum et al, 2013)
This meeting has clearly demonstrated that Pontin and Reptin are no longer only exciting and sophisticated objects for fundamental studies, but are implicated as regulators of essential processes in development and physiology, in the response to pathogens, and that their deregulation contributes to the pathogenesis of several diseases including cancer
Summary
Pontin and Reptin are related partner proteins belonging to the AAA+ (ATPases Associated with various cellular Activities) family. They came to attention in the late 1990s and it became rapidly clear that they were implicated in multiple and seemingly unrelated processes encompassing the regulation of gene transcription, the remodeling of chromatin, DNA damage sensing and repair, and the assembly of protein and ribonucleoprotein complexes among others (Gallant, 2007; Huber et al, 2008; Jha and Dutta, 2009; Cheung et al, 2010; Nano and Houry, 2013). Similar to RuvB they have an ATPase activity but their helicase activity remains questioned Both proteins can form oligomers like homo-hexamers, hetero-hexamers, or hetero-dodecamers (Figure 1)
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