Abstract
BackgroundRecently, it has been reported that the A930G and C242T polymorphisms within p22phox (CYBA) gene are involved in the pathogenesis of hypertension. However, the results remain controversial. Furthermore, no previous meta-analysis has been conducted to evaluate the relationship between the A930G and C242T polymorphisms and hypertension. Therefore, we performed this meta-analysis to clarify these controversies.Objective and MethodsAll of the included articles were retrieved from the PubMed and Embase databases, as well as the CNKI, CBM, Chongqing VIP and Wan Fang databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Odds ratios (OR) with corresponding 95% confidence intervals (CI) were used to assess the strength of the association. Accounting for heterogeneity, a fixed or random effects model was respectively adopted. Heterogeneity was checked using the Q test and the I2 statistic. A cumulative meta-analysis was conducted to estimate the tendency of pooled OR. Funnel plots and Egger’s tests were performed to test for possible publication bias.ResultsFive articles on A930G with 2003 cases/2434 controls and eight articles on C242T with 2644 cases/1967 controls were identified. A significant association of A930G polymorphisms with the risk of hypertension was found in the dominant model (OR=0.59, 95% CI: 0.38–0.92, p=0.021) and allelic model (OR=0.66, 95% CI: 0.46–0.95, p=0.024). In the stratified analysis, a significant association could be found among the hospital-based and population-based studies. However, no evidence of a significant association of the C242T polymorphism with hypertension was found in the overall analysis and subgroup analysis.ConclusionsThis meta-analysis indicates that the A930G polymorphism, but not the C242T variation, might be a protective factor for hypertension.
Highlights
Hypertension is considered a major public health issue [1] that affects nearly one billion people worldwide [2]
Selection criteria All the included original studies were selected according to the following inclusion criteria: a) studies evaluating the association between CYBA A930G or C242T polymorphisms and hypertension; b) case-control or cohort studies; c) sufficient data provided with information on the genotypes and allele frequencies
The diagnostic criteria for hypertension were different among the studies: patients in three studies were diagnosed according to systolic blood pressure(SBP) and/or diastolic blood pressure (DBP) greater than 140 and 90 mmHg, patients in one study were diagnosed according to SBP and/or DBP greater than 139 and 89 mmHg, and the diagnostic criteria were not mentioned in one study
Summary
Hypertension is considered a major public health issue [1] that affects nearly one billion people worldwide [2]. It is recognized as the leading contributor to death and disability globally [3], and the prevalence is dramatically increasing [4,5]. No previous meta-analysis has been conducted to evaluate the relationship between the A930G and C242T polymorphisms and hypertension. We performed this meta-analysis to clarify these controversies. Conclusions: This meta-analysis indicates that the A930G polymorphism, but not the C242T variation, might be a protective factor for hypertension
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
