Abstract
Background. Acute coronary syndrome (ACS) has an important impact in public health with high morbidity and mortality. Prothrombotic and proinflammatory states are involved in the pathogenesis of the disease. Plasminogen activator inhibitor-1 (PAI-1) is the major inhibitor of the fibrinolysis and also is part of immune response. The -844 G>A gene polymorphism is related to increased PAI-1 protein levels. The aim of the study is to evaluate the association of -844 G>A PAI-1 polymorphism with ACS. Methods. A total of 646 individuals were recruited from Western Mexico: 350 unrelated healthy subjects and 296 patients with diagnosis of ACS. Results. The most important risk factor in our population was hypertension, followed by smoking. The genetic distribution showed an association of the A allele (OR = 1.27, P = 0.04) and AA genotype (OR = 1.86, P = 0.02) with ACS. The recessive model displayed similar results (OR = 1.76, P = 0.02). As additional finding, we observed significant differences in the genetic distribution of ACS dyslipidemic patients (OR = 1.99, P = 0.04). The A allele and AA genotype of -844 polymorphism of PAI-1 gene are risk factors for ACS. The AA genotype might be associated with the development of dyslipidemia in ACS patients.
Highlights
Acute coronary syndrome (ACS) is a growing concern around the world, a leading cause of death, and an important cause of disability [1, 2]. It is defined as a clinical group of entities which have as a common physiopathological mechanism the rupture of a plaque with thrombosis leading to acute myocardial ischemia
Other studies had similarities in the occurrence of risk factors with our population [22]. As it was established previously, we found differences in the genetic distribution in the healthy subjects (HS) group compared with other populations, including Europeans, Asians, and Sub-Sahara Africans, but not with the African American group and a previous report of Western Mexicans [16]
We found an association of -844 G>A polymorphism with ACS
Summary
Acute coronary syndrome (ACS) is a growing concern around the world, a leading cause of death, and an important cause of disability [1, 2] It is defined as a clinical group of entities which have as a common physiopathological mechanism the rupture of a plaque with thrombosis leading to acute myocardial ischemia. ACS is a complex disease in which environmental and genetic factors play an interrelated role in its progress. It begins with an altered lipid metabolism and an inflammatory response, followed by the development of an atherosclerotic plaque. The A allele and AA genotype of -844 polymorphism of PAI-1 gene are risk factors for ACS. The AA genotype might be associated with the development of dyslipidemia in ACS patients
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