Abstract
BackgroundPeptidyl-prolyl cis–trans isomerase NIMA-interacting 1 (PIN1) plays an important role in cancer development. The relationship between PIN1 −842G/C (rs2233678) polymorphism and cancer risk was inconclusive according to published literature.Methodology/Principal FindingsA literature search, up to February 2013, was carried out using PubMed, EMBASE and the China National Knowledge Infrastructure (CNKI) database. A total of 10 case-control studies including 4619 cases and 4661 controls contributed to the quantitative analysis. Odds ratio (OR) and 95% confidence intervals (95% CI) were used to assess the strength of association. Overall, individuals with the variant CG (OR = 0.728, 95% CI: 0.585,0.906; Pheterogeneity<0.01) and CG/CC (OR = 0.731, 95% CI: 0.602,0.888; Pheterogeneity<0.01) genotypes were associated with a significantly reduced cancer risk compared with those with wild GG genotype. Sub-group analysis revealed that the variant CG (OR = 0.635, 95% CI: 0.548,0.735; Pheterogeneity = 0.240) and CG/CC (OR = 0.645, 95% CI: 0.559,0.744, Pheterogeneity = 0.258) genotypes still showed an reduced risk of cancer in Asians; while no significant association was observed in Caucasians (CG vs.GG: OR = 0.926, 95% CI: 0.572,1.499, Pheterogeneity<0.01; CG/CC vs. GG: OR = 0.892, 95% CI: 0.589,1.353; Pheterogeneity<0.01). Furthermore, sensitivity analysis confirmed the stability of results. Begg's funnel plot and Egger's test did not reveal any publication bias.ConclusionsThis meta-analysis suggests that the PIN1 −842G/C polymorphism is associated with a significantly reduced risk of cancer, especially in Asian populations.
Highlights
Pro-directed phosphorylation is a critical signaling mechanism in various cellular processes, including transcription, RNA processing, cell cycle progression, cell proliferation and differentiation [1,2,3]
These findings suggest that prolyl cis–trans isomerase NIMA-interacting 1 (PIN1) may play an important role in cancer development
In the study reported by Naidu R and colleagues [15], participants were recruited from three different populations (Malay, Chinese, and Indian), and the genotype frequencies were presented separately, each of them was considered as a separate study in this meta-analysis
Summary
Pro-directed phosphorylation is a critical signaling mechanism in various cellular processes, including transcription, RNA processing, cell cycle progression, cell proliferation and differentiation [1,2,3]. It has been demonstrated that PIN1 is associated with different signaling pathways such as cellcycle progression, cellular proliferation, as well as neoplastic transformation [6,7]. Its expression levels parallel the malignant properties in several types of cancer, such as lung cancer, colon cancer, breast cancer, prostate cancer, and oral squamous cell carcinoma [10,11,12,13]. These findings suggest that PIN1 may play an important role in cancer development. Peptidyl-prolyl cis–trans isomerase NIMA-interacting 1 (PIN1) plays an important role in cancer development. The relationship between PIN1 2842G/C (rs2233678) polymorphism and cancer risk was inconclusive according to published literature
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