Abstract
7-Aza-bicyclo-[2.2.1]heptane (7-aza-norbornane) is a bridged heterocyclic nucleus found in epibatidine, the alkaloid isolated from the skin of the tropical poison frog Epipedobates tricolor. Since epibatidine is known as one of the most potent acetyl-choline nicotinic receptor agonists, a plethora of literature has been devoted to this alkaloid. However, there are no structural data on the unsubstituted 7-aza-norbornane, the parent bicyclic ring of epibatidine and its derivatives. We herein present the structural characterization of the 7-aza-bicyclo-[2.2.1]heptane parent ring as its hydro-chloride salt, namely 7-aza-bicyclo-[2.2.1]heptan-7-ium chloride, C6H12N+·Cl-. The compete cation is generated by a crystallographic mirror plane with the N atom lying on the mirror, as does the chloride anion. In the crystal, the cations are linked to the anions by N-H⋯Cl hydrogen bonds, which generate [001] chains.
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Schedule a callMore From: Acta crystallographica. Section E, Crystallographic communications
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