Abstract
The 4,5-methano-l-proline was studied for the direct asymmetric aldol reaction of acetone or cyclohexanone with various aromatic and aliphaticaldehydes at −20 °C or 0 °C. A loading of only 5mol % of derivative 1a was employed in this catalytic system, and excellent enantioselectivities (up to 99% ee) and yields (up to 98% yield) could be achieved.
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