Abstract
Compared with 2D tumor cell culture, 3D tumor cell culture can better simulate the microenvironment of signal transduction between cells and extracellular matrix. As one of the best cell models in tumor research, it has been widely used in the study of cancer cell morphology, nanotechnology drug delivery system, and anticancer drug screening. The main theme of this paper is to review the previous research of 3D cell culture applying to tumors in vitro and the prospects for the applications of 3D cell culture system.
Highlights
Compared with 2D tumor cell culture, 3D tumor cell culture can better simulate the microenvironment of signal transduction between cells and extracellular matrix
As one of the best cell models in tumor research, it has been widely used in the study of cancer cell morphology, nanotechnology drug delivery system, and anticancer drug screening
The main theme of this paper is to review the previous research of 3D cell culture applying to tumors in vitro and the prospects for the applications of 3D cell culture system
Summary
2-dimensional (2D) culture means a method of culturing tutors by building models outside the body in two dimensions. Regarding as the 3-dimensional (3D) culture, it is a way to culture tissues but one more dimension than 2D culture. Tumoris anartificial tissue, is established outside of bodies as a model to culture in vitro tumors for better tumor research. The previous work on the three-dimensional (3D) cell culture system has indicated that the morphology and function of isolated cells in 3D culture are closer to the real growth state of these cells in vivo comparing the traditional two-dimensional (2D) cell culture [1]. 2D cell culture oversimplifies the various processes that Nano-medicine reaches its targeted site in vivo.
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