Abstract
Aim: Sentinel node biopsy is a prognostic indicator of melanoma recurrence. We hypothesized that adding the primary melanoma molecular signature from the 31-gene expression profile (31-GEP) test could refine the risk of recurrence prognosis for patients with stage I-III melanoma. Materials & methods: Four hundred thirty-eight patients with stage I-III melanoma consecutively tested with the 31-GEP were retrospectively analyzed. The 31-GEP stratified patients as low-risk (Class 1A), intermediate-risk (Class 1B/2A)or highrisk (Class 2B) of recurrence or metastasis. Results: The 31-GEP significantly stratified patient risk for recurrence-free survival (p<0.001), distant metastasis-free survival (p<0.001)and melanoma-specific survival (p<0.001) and was a significant, independent predictor of metastatic recurrence (hazard ratio: 5.38;p= 0.014). Conclusion: The 31-GEP improves prognostic accuracy in stage I-III melanoma.
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