Abstract
Acute myocardial infarction is a highly prevalent cardiovascular disease in Taiwan. Among several etiological risk factors, obesity and inflammation are strongly associated with the frequency of hypertension, cardiovascular disease, diabetes, and myocardial infarction. To discriminate obesity- and inflammation-related genes and the onset of acute myocardial infarction (AMI), a case-control study was conducted to investigate the association of the -308G/A polymorphisms of tumor necrosis factor (TNF)-α and the C825T polymorphism of guanidine nucleotide binding protein 3 (GNB3) with the onset of AMI among Taiwanese cohorts. A total of 103 AMI patients and 163 matched normal control samples were enrolled in the present study. The genomic DNA was extracted and subjected into polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analysis. An association between the A homozygosity of the TNF-α-308G/A polymorphism and the onset of AMI was observed among the male subjects (p = 0.026; Spearman index = 0.200, p = 0.008). An association between the T homozygosity of GNB3 C825T polymorphism and obesity was also observed (Fisher’s exact, p = 0.009). The TT genotype has a protective effect against acquiring AMI among the obese female population in Taiwan (Fisher’s exact, p = 0.032). In conclusion, TNF-α-308G/A and the GNB3 C825T polymorphisms are associated with obesity and AMI in the Taiwanese population.
Highlights
Acute myocardial infarction (AMI) is one of the leading causes of death worldwide
We aim to investigate the association between the -308G/A polymorphisms of tumor necrosis factor (TNF)-α and the C825T polymorphism of guanidine nucleotide binding protein 3 (GNB3) in terms of the onset of acute myocardial infarction (AMI) among Taiwanese cohorts
No differences were observed in the genetic frequency distribution of the Tumor necrosis factor-α (TNF-α)-308G/A polymorphism when the AMI patients were compared with the normal subjects
Summary
Acute myocardial infarction (AMI) is one of the leading causes of death worldwide. AMI has a high prevalence in Taiwanese cohorts, especially the elderly [1]. The age of AMI onset has decreased because of environmental risk factors and genetic polymorphisms [2]. The -308G/A polymorphism in the promoter region of TNF-α is associated with its expression and effects, such as in lipid metabolism, insulin resistance, and endothelial function in cardiovascular disease [3]. A higher frequency of carriers of the A allele is observed in patients with unstable angina. A more striking association between A allele carriage frequency and unstable angina is found in patients with a body mass index (BMI) ≤ 27 (p = 0.012; odds ratio = 3.0) [4]. The association between the A allele carriage frequency and the development of atherosclerosis, as well as the presence of family history of coronary heart disease is observed [5].
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