Abstract
We show that perdeuterated side chain of leucine amino acid and related compounds can serve as a useful structural reporter, suitable for studying proteins using two-dimensional infrared (2DIR) spectroscopy. Strong direct-coupling C-D/C=O and C-D/Am-II cross-peaks were measured by dual-frequency 2DIR in these compounds. The direct-coupling cross peaks were further enhanced up to 5 fold using the relaxation-assisted 2DIR method. The energy transport times (arrival times) and amplification factors were measured and used to assign the C-D absorption peaks and these assignments were compared with the results of anharmonic DFT calculations.KeywordsArrival TimeCross PeakEster HydrochlorideLinear SpectrumLeucine Amino AcidThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
