The 2–5A (pppA 2′ p 5′ A 2′ p 5′ A) system in interferon-treated and control cells

Abstract

An investigation into the inhibition of protein synthesis by double-stranded RNA in cell-free systems prepared from interferon-treated cells has resulted in the identification of at least two enzymes (the 2–5A synthetase and protein kinase) which are induced in response to interferon. In addition, the discovery that the 2–5A synthetase is present in a wide variety of cells and tissues in the absence of interferon treatment and is also capable of using important metabolites as substrates has suggested a possible wider significance for the 2–5A system in the control of cell growth and development.