Abstract
Chronic hepatitis B virus (HBV) infection is a serious public health issue. Vitamin D is involved in various pathophysiological mechanisms as an immune modulator and the deficiency rate of vitamin D is prevalent in chronic liver disease. Fucoidan exerts anti-inflammatory, anticoagulant, antitumor, antimetastatic, and antiangiogenetic effects; however, its effect on the immune responses of HBV patients is unclear. This study investigated how 25(OH)Vitamin D status affected the effectiveness of oligo fucoidan in patients with HBV infection in the immune tolerance phase. Fifty-one patients received oligo fucoidan 4400 mg/day for 48 weeks. Flow cytometry was used to detect T lymphocyte markers (CD3+CD4+, CD3+CD8+, CD4+CD45RO+, CD8+CD45RO+). The levels of white blood cell (WBC), platelets (PLT), and albumin were decreased after 48 weeks of supplementation (p < 0.05). Percentages of CD3+CD8+ and CD8+CD45RO+ cells were decreased after 12 weeks of supplementation (p < 0.05). In patients with adequate vitamin D, HBV-DNA concentrations decreased and the proportion of CD4+CD45RO+ and CD8+CD45RO+ cells increased upon oligo fucoidan supplementation. The HBeAg status of one vitamin D-adequate patient changed from positive to negative at the 12th week of supplementation. The oligo fucoidan may regulate immune effects in patients with HBV infection, and the 25(OH)Vitamin D status might have affected the effectiveness of oligo fucoidan.
Highlights
Hepatitis B virus (HBV) infection is a global disease
The use of fucoidan treatment for viral hepatitis has shown no adverse effects and has good therapeutic effects in patients with chronic hepatitis C [26]. It is not clear whether it is effective in patients with chronic hepatitis B; the purpose of this study is to determine the effects of supplementation with fucoidan in patients with chronic hepatitis B and liver function ALT less than twice the healthy upper limit (>40 units/L and
A total of 51 patients with chronic hepatitis B were enrolled in this study
Summary
Hepatitis B virus (HBV) infection is a global disease. Approximately two billion people worldwide have been infected with HBV, more than 350 million people are chronic carriers [1], and more than780,000 die each year from acute or chronic HBV infection [2]. Hepatitis B virus (HBV) infection is a global disease. Two billion people worldwide have been infected with HBV, more than 350 million people are chronic carriers [1], and more than. 780,000 die each year from acute or chronic HBV infection [2]. In North America, the prevalence of asymptomatic hepatitis B in adults is 0.5%; the prevalence of asymptomatic adults in Taiwan is about. 15%, indicating that Taiwan is a high-prevalence area of HBV infection. A hepatitis B vaccine program for newborns with hepatitis B surface antigen-positive mothers has existed since July 1984 in Taiwan. In July 1986, hepatitis B vaccination of infants and young children was fully implemented. Thereafter, the hepatitis B carrier rate of six-year-old children significantly decreased from 10.5% in 1989 to 0.8%
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