Abstract
ObjectiveTo assess the role of c. 2039 A/G (p. Asp680Ser) (rs6166) and c. −29 G/A (rs1394205) follicle-stimulating hormone receptor (FSHR) gene single nucleotide polymorphisms (SNPs) in a cohort of healthy men.MethodsOne-hundred twenty-seven healthy men underwent evaluation of the anthropometric parameters, assessment of metabolic and lipid profile, measurement FSH serum levels, and genotyping of both the aforementioned FSHR SNPs. Data grouped according to the FSHR rs6166 or rs1394205 genotypes underwent to statistical analysis.Main resultsThe three groups of men for each FSHR SNP did not differ statistically significantly for body mass index and serum FSH levels. As for FSHR rs6166 SNP, glucose levels were significantly lower in men with the GG genotype compared with those with the AA genotype. Men with AG had lower insulin levels and HOMA index values compared with those carrying the genotype AA (p < 0.05). The GG group showed a negative correlation between serum FSH levels and insulin and between serum FSH levels and HOMA index (p < 0.05). In contrast, men grouped according to the FSHR rs1394205 genotype showed no significant difference in blood glucose, serum insulin levels, and HOMA index. The AG group showed a negative correlation between FSH insulin and between serum FSH levels and HOMA index (p < 0.05).ConclusionsMen with the genotype GG of the FSHR rs6166 SNP have lower blood glucose levels than those with the AA genotype. Their FSH levels inversely correlated with insulin and HOMA index. In contrast, the genotype FSHR rs6166 A/G did not reveal any role of FSH on glucose metabolism in healthy men. The inverse relationship between FSH and insulin or HOMA index in the group with the genotype GG of the FSHR rs6166 SNP suggests a possible cross-talk between FSH and insulin.
Highlights
The follicle-stimulating hormone (FSH) is a glycoprotein made of an α and a β subunit
The results of the present study showed that the polymorphism rs6166 in exon 10 of the follicle-stimulating hormone receptor (FSHR) gene influences significantly blood glucose levels in healthy men
Since the groups resulted to have a similar age, body mass index (BMI) and FSH levels, these findings suggest that the FSHR gene plays a role on glucose metabolism in men
Summary
The follicle-stimulating hormone (FSH) is a glycoprotein made of an α and a β subunit. It exerts its peripheral effects by binding to its receptor (FSHR), a 678 amino acid protein belonging to the G-coupled receptor family, expressed in. The follicle-stimulating hormone receptor (FSHR) gene, mapping in the 2p16.3 chromosome, contains ten exons and nine introns. The first nine exons encode for the majority of the extracellular domain. The exon 10 encodes for the Cterminal region of the extracellular domain, the transmembrane and the intracellular domains [1]. The first maps in the exon 10, which encodes for the transmembrane domain of the FSHR, and it is known to influence the efficiency of signal transduction. The c. 2039 A/G genotype impacts on the expression of the amino acid 680 and the FSHR Ser680Ser
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