Abstract

On April 26-27, 2013, the Step by Step Foundation hosted the Second International Spinal Cord Repair Meeting at the Fira Barcelona Convention Center in Hospitalet de Llobregat, Spain, highlighting some of the exciting research including clinical trials which show promise for treatments for this devastating disorder. This meeting brought together clinicians, clinical scientists and molecular biologists from more than 10 countries to evaluate current knowledge on clinical, cellular, and biomolecular aspects of spinal cord injury. A major goal of the conference in advancing the translation of research data to the clinic was to promote multi-pronged approaches for therapy of this complex problem.

Highlights

  • Spinal cord injury (SCI) is a major cause of long-term disability with no clinically effective treatment, devastating the lives of those affected as well as their families

  • Improved locomotor recovery and a significantly higher rate of axons crossing the lesion site in treated animals were observed. With these convincing data in hand, and the long-established safety parameters of vitamin D in human, Dr Féron will lead with Dr Roche a phase II multicentric, randomised, double blind clinical trial to assess the efficacy of cholecalciferol in patients with a cervical trauma

  • This second international conference organized by the Step by Step foundation succeeded in bringing together high profile international speakers, delivering frontline news, with a mixed audience of clinicians, researchers and patients

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Summary

INTRODUCTION

Spinal cord injury (SCI) is a major cause of long-term disability with no clinically effective treatment, devastating the lives of those affected as well as their families. Biomedical Science and Engineering 6 (2013) 21-32 variety of treatments including growth factors, glial scar neutralizing agents, grafts of glial and stem cells (both embryonic and adult), can promote spinal cord repair and functional recovery after a lesion. The Step by Step (SbyS) Foundation, hosted this 2nd International Spinal Cord Repair Meeting, is a nonprofit organization dedicated to the recovery of people suffering from neurological disorders of the CNS, SCI and stroke. Amongst other activities SByS has hosted two International Spinal Cord Repair meetings to bring together researchers, clinicians and patients to discuss and evaluate ongoing laboratory experiments and clinical trials with the aim of promoting interchange of experiences from the different fields, of world experts dedicated to understanding the complex problem of SCI and its treatment. Amongst other activities SByS has hosted two International Spinal Cord Repair meetings to bring together researchers, clinicians and patients to discuss and evaluate ongoing laboratory experiments and clinical trials with the aim of promoting interchange of experiences from the different fields, of world experts dedicated to understanding the complex problem of SCI and its treatment. http://www.fundacionsbs.org/en/ http://www.spinalcordmeeting.org/

SPINAL CORD REPAIR AS A FORM OF WOUND HEALING
NERVE GRAFTS AND TROPHIC FACTORS
THE WNT FAMILY AS THERAPEUTIC TARGETS
A VITAMIN D CLINICAL TRIAL IN PARAPLEGIC PATIENTS
TARGETED DRUG DELIVERY BY GENE TRANSFER FOR SPINAL CORD INJURY PAIN
A Clinical Trial with Human Neural Stem Cells
Neural Stem Cells in Rat SCI Models
Neural Stem Cell Transplants in Mouse SCI Models
DISCUSSION AND CONCLUSIONS
10.1. Moving iPS Cell Technology Closer to the Clinic
10.4. Cell and Gene Therapy Approaches for Regeneration of Spinal Cord Neurons
10.7. Connexins in Neural Precursor Cells Reprogramming
10.9. Motor Assessment of Syringomyelia Model in Rats
10.11. Phenotype Interconversion in Human Neural Stem and Progenitor Cells
10.12. Plasticity in Lumbar Segments after Spinal Cord Injury
10.13. Role of Lysophosphatidic Acid in the Pathophysiology of Spinal Cord Injury
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