Abstract
The URNCST Journal Case Competition provides undergraduate students with the opportunity to experience the peer review and publication process through participate in a case competition. Participants submit an abstract of a research protocol based on a topic proposed by the URNCST Journal. The following abstracts were submitted by undergraduate students to the 1st URNCST Journal Case Competition held during September 2018. This case competition’s topic was new and innovative solutions for the prevention, diagnosis, treatment, and care of Alzheimer’s disease. To learn more about this abstract competition and submit your own, please visit: https://urncst.com/index.php/competition/about.
Highlights
Alzheimer’s disease (AD) is a prevalent form of dementia characterized by degenerating physiological and neurological function
Through assessment of Aβ42/p-tau181 levels in the cerebrospinal fluid (CSF) and its impact on cognitive impairment quantified by Montreal Cognitive Assessment (MoCA), it is anticipated that patients that receive Hyperbaric Oxygen Therapy (HBOT) will show stabilized or slowed cognitive decline
Results will indicate if greater benefit of HBOT is expected at certain Aβ42/p-tau181.levels
Summary
Alzheimer’s disease (AD) requires early detection and treatment to delay rapid neurodegeneration into late stages involving severe memory and daily-living impairments. This research seeks to apply a transgenic model to identify the average duration up to which the cholinergic inhibitor, donepezil, promotes cognitions and the fluctuations in acetylcholine levels as a function of medication through microdialysis. Conclusion: The effectiveness of donepezil in improving cognitive impairments of AD has yet to be analyzed through comparisons of medication dosage and temporal distance This protocol aims to measure acetylcholine levels and the duration whereat inhibitors exert alleviating effects upon symptomatology. JYN: Designed and founded the URNCST Journal Case Abstract Competition, ensured abstracts adhered to correct formatting standards, assisted authors with their abstract submissions, sourced and assigned peer-reviewers, reviewed the drafted abstract booklet, and gave final approval of the version to be published
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