Abstract
Conjugated linoleic acid (CLA) is a mixture of positional and geometric isomers of linoleic acid found in beef, lamb, and dairy products. CLA has attracted considerable attention over the past several decades because of its potentially beneficial biological effects, including protective effects against several cancers, atherosclerosis, and obesity. Here we provide the first evidence that the 10 trans,12 cis-CLA isomer is able to suppress increases in blood pressure during the onset of obesity in OLETF rats. After 3 weeks of feeding with 10 t,12 c-CLA, systolic blood pressure was significantly lowered compared with rats fed linoleic acid or 9 c,11 t-CLA. Abdominal adipose tissue weight was also significantly lowered in rats fed 10 t,12 c-CLA, but not in those which were fed 9 c,11 t-CLA. In addition, we found that the relative mRNA expressions of angiotensinogen and leptin were suppressed by 10 t,12 c-CLA in adipose tissue. We speculate that the antihypertensive effect of 10 t,12 c-CLA can be attributed to the lowered secretion of hypertensive adipocytokines from abdominal adipose tissues.
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