Abstract
Ca2+ channel β subunits (Cavβs) are essential for the surface expression and proper gating of high-voltage activated (HVA) Ca2+ channels. In yeast two-hybrid screens aimed at discovering novel Cavβ-interacting proteins, we identified a new splicing isoform of Pax6, a transcription factor crucial for the development of a variety of organs and tissues, especially the eye. Pax6 contains two DNA-binding domains (paired domain and homeodomain), a glycine-rich linker connecting these two domains, and a carboxyl (C)-terminal proline, serine and threonine (PST)-rich transactivation domain.
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