Abstract
The chemokine stromal-derived factor-1α (SDF-1α) and its receptor CXCR4 are critically involved in directional migration and homing of plasma cells in multiple myeloma. Here, we show that the expression of SDF-1α and CXCR4 was significantly down-regulated in patients treated with thalidomide ( n = 10) as compared to newly diagnosed MM patients ( n = 31) and MM patients treated with other drugs ( n = 38). SDF-1 α and CXCR4 expression was also significantly decreased in a RPMI 8226 cell line treated with 10 and 20 μmol/L of thalidomide. Our findings indicate that thalidomide therapy induces down-regulation of CXCR4 and its ligand SDF-1α in multiple myeloma.
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