Abstract
Results Daily oral dose of thalidomide was able to reduce in 46% the tumor volume. Assessment of tumor vascularization revealed a significant decrease in blood vessels formation by thalidomide. The levels of two cytokines, VEGF and TNF-a were decreased in tumor samples of thalidomidetreated group compared with the control group. Accumulation of neutrophils or macrophages in the 4T1 tumor measured by the activities of inflammatory enzymes, MPO for neutrophils and NAG for macrophages, was inhibited by the treatment. Conclusions By targeting key components of 4T1 tumor simultaneously, thalidomide was effective in attenuating tumor growth. This approach, suppression of inflammation and angiogenesis may provide further insights for both prevention and treatment of cancer.
Highlights
Thalidomide has proven to exert anti-inflammatory, antiproliferative and anti-angiogenic activities in both neoplastic and non-neoplastic conditions
We investigated the effects of this compound on blood vessel formation, inflammatory cell recruitment/activation and cytokine production of 4T1 mammary tumor in mice
Published: 4 April 2013 doi:10.1186/1753-6561-7-S2-P18 Cite this article as: Souza et al.: Thalidomide inhibits inflammation and angiogenesis in tumor 4T1 growth in mice
Summary
Cristina M Souza[1], Cecília B Campos[1], Ana CA Silva[3], Míriam P Lopes[3], Mônica AND Ferreira[1,2], Silvia P Andrade[2], Geovanni D Cassali1*. From São Paulo Advanced School of Comparative Oncology Águas de São Pedro, Brazil. From São Paulo Advanced School of Comparative Oncology Águas de São Pedro, Brazil. 30 September - 6 October 2012
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
