Thalamic afferents of the rat infralimbic and lateral agranular cortices

Abstract

The infralimbic cortex is a visceromotor area of the cortex. To define the thalamic afferents of this area, contrast them with those of the lateral agranular cortex, a somatic motor region, and assess the degree to which the thalamus might coordinate the activity of these cortical areas through axon collaterals, we conducted a retrograde fluorescent double labeling study using bisbenzimide and Fast Blue. Injections into infralimbic cortex resulted in labeling in the mediodorsal, intralaminar, and midline nuclei. Injections into lateral agranular cortex resulted in labeling in the ventrolateral, ventrobasal, ventromedial, and intralaminar nuclei. There was almost no overlap in the thalamic labeling following injections into these two cortical areas. The pattern of labeling following infralimbic injections is discussed in terms of the possible function of the midline thalamic nuclei as a relay for visceral sensory information. The labeling in mediodorsal nucleus following infralimbic cortex argues for including this area in the definition of rodent prefrontal cortex. In addition, the results suggest that the role of the thalamus in coordinating the activity of these cortical areas is minimal.