Abstract

RATIONALE: The CDC recommends that AD patients should not be voluntarily vaccinated against smallpox due to the potential development of eczema vaccinatum. The cathelicidin anti-microbial peptide family exhibits anti-viral activity against vaccinia virus (VV) and is deficient in AD skin. Current studies were carried out to better understand the relationship between VV replication and cathelicidin expression in AD versus normal skin.

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