Abstract
Background Circulating Vdelta2 T lymphocytes are involved in the response to mycobacteria and certain viruses, while Vdelta1 T cells, resident in the mucosal tissues, participate in the immunity against intracellular microrganisms. Vdelta2 T cells recognize non-peptidic phosphorylated antigens expressed by mycobacteria, whereas Vdelta1 T cells interact with MHC-related molecules (MICA, MICB) and with receptors for the UL-16 protein produced by CMV-infected cells. Vdelta1 T cells release IFNgamma upon challenge with MICA cells, while Vdelta2 T cells secrete this cytokine upon stimulation with phosphate antigens. We reported that in early HIV1 infection Vdelta1 T lymphocytes, producing IFNgamma, are increased in the peripheral blood. We addressed the question of whether this T cell subset can also be involved in the response to fungal infections.
Highlights
Circulating Vdelta2 T lymphocytes are involved in the response to mycobacteria and certain viruses, while Vdelta1 T cells, resident in the mucosal tissues, participate in the immunity against intracellular microrganisms
Vdelta2 T cells recognize non-peptidic phosphorylated antigens expressed by mycobacteria, whereas Vdelta1 T cells interact with MHC-related molecules (MICA, MICB) and with receptors for the UL-16 protein produced by CMV-infected cells
We show that: 1) a population of circulating Vdelta1 T lymphocyte producing both IFN-gamma and IL-17 is expanded in HIV-1 infected patients; 2) this population is capable of proliferating and enhancing cytokine production in response to Candida albicans, while Vdelta2 T cells respond to mycobacterial antigens; 3) IFN-gamma/IL-17 double producers express the RORC and the TXB21 transcription factors, the CCR7 homing receptor, the CD161 molecule involved in transendothelial migration, and the CCR4 and CCR6 chemokine receptors
Summary
Alessandro Poggi1*, Daniela Fenoglio, Florinda Battaglia, Silvia Catellani, Alessandra Musso, Maurizio Setti, Giuseppe Murdaca, Maria Raffaella Zocchi. From 16th International Symposium on HIV and Emerging Infectious Diseases Marseille, France. From 16th International Symposium on HIV and Emerging Infectious Diseases Marseille, France. 24-26 March 2010
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