TH1 and TH2 cytokines dataset in insulin users with diabetes mellitus and newly diagnosed breast cancer

Zachary A.P Wintrob,Jeffrey P Hammel,George K Nimako,Dan P Gaile,Alan Forrest,Alice C Ceacareanu

doi:10.1016/j.dib.2017.02.028

Abstract

Exogenous insulin use may interfere with the T helper cells’ cytokine production. This dataset presents the relationship between pre-existing use of injectable insulin in women diagnosed with breast cancer and type 2 diabetes mellitus, the T-helper 1 and 2 produced cytokine profiles at the time of breast cancer diagnosis, and subsequent cancer outcomes. A Pearson correlation analysis evaluating the relationship between T-helper cytokines stratified by of insulin use and controls is also provided.

Highlights

TH1 and TH2 cytokines dataset in insulin users with diabetes mellitus and newly diagnosed breast cancer
Exogenous insulin use may interfere with the T helper cells’ cytokine production. This dataset presents the relationship between pre-existing use of injectable insulin in women diagnosed with breast cancer and type 2 diabetes mellitus, the T-helper 1 and 2 produced cytokine profiles at the time of breast cancer diagnosis, and subsequent cancer outcomes
A Pearson correlation analysis evaluating the relationship between T-helper cytokines stratified by of insulin use and controls is provided

Summary

Data accessibility

Tables Tumor registry query was followed by vital status ascertainment, and medical records review Luminexs-based quantitation from plasma samples was conducted for the following T-helper 1 and T-helper 2 cytokines: Interleukine-2, soluble interleukine-2 receptor α, interleukine-12 subunit p40, interleukine-12 subunit p70, interferon α 2, interferon γ, chemokine ligand 10 (interferon gammainduced protein 10), chemokine ligand 9 (monokine-induced by interferon γ), chemokine ligand 8 (interleukine-8) interleukine-5, interleukine-10, and interleukine-13. United States, Buffalo, NY - 42° 530 50.359200N; 78° 520 2.65800W This dataset represents the observed relationship between administration of exogenous insulin, circulating T-helper 1 and 2 produced cytokines at breast cancer diagnosis and cancer outcomes. Reported data represents the observed association between pre-existing use of injectable insulin before breast cancer diagnosis and the T-helper 1 and 2 produced cytokine profiles upon cancer diagnosis in women with both breast cancer and diabetes mellitus (Table 1). Evaluation of the association between profiles of T-helper 1 and 2 produced cytokines, injectable insulin use and BC outcomes was carried out under two protocols approved by both Roswell Park Cancer Institute (EDR154409 and NHR009010) and the State University of New York at Buffalo.

Inclusion and exclusion criteria

Control-matching approach

Demographic and clinical data collection

Plasma specimen storage and retrieval

Luminexs assays

Biomarker-pharmacotherapy association analysis