Abstract
Transforming growth factor beta 1(TGF‐β1) polymorphism was associated with radiation pneumonitis (RP) susceptibility, but their results have been inconsistent. The PubMed and CNKI were searched for case‐control studies published up to Januray 01, 2016 was Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. In this meta‐analysis, we assessed eight publications involving 368 radiation pneumonitis cases and 855 controls of the association between TGF‐β1 T869C (rs1982073) and G915C (rs1800471) polymorphism and RP susceptibility. Our analysis suggested that TGF‐β1 T869C rs1982073 polymorphism was associated with lower RP risk for CT combined CC versus TT model (OR = 0.58, 95% CI = 0.43–0.77). However, for the G915C rs1800471 polymorphism, no association was found between the polymorphism and the susceptibility to RP in GC combined CC versus GG model (OR = 0.82, 95% CI = 0.50–1.35). These results from the meta‐analysis suggest that T869C rs1982073 polymorphism of TGF‐β1 may be associated with RP risk, and there may be no association between G915C polymorphism and RP risk.
Highlights
Lung cancer remains the deadliest cancer worldwide despite improvements in diagnostic and therapeutic techniques [1]
Radiation pneumonitis (RP) is a dose-limiting factor for radiotherapy and have a major influence on patients prognosis and life quality, which occurs in 5–15% of people who go through radiation therapy for lung cancer
Many factors can influence the severity of reaction to radiotherapy, a large part of interpatient variability attribute to the individual differences in radio-sensitivity, which was assumed to be determined by genetic variations among patients [4]
Summary
Lung cancer remains the deadliest cancer worldwide despite improvements in diagnostic and therapeutic techniques [1]. Radiotherapy is an important and commonly used modality in lung cancer treatment, but normal tissues in the vicinity of the target area of the radiation beam are inevitably irradiated [3]. Radiation pneumonitis (RP) is a dose-limiting factor for radiotherapy and have a major influence on patients prognosis and life quality, which occurs in 5–15% of people who go through radiation therapy for lung cancer. Many factors can influence the severity of reaction to radiotherapy, a large part of interpatient variability attribute to the individual differences in radio-sensitivity, which was assumed to be determined by genetic variations among patients [4]. TGF-b1 gene is one of the most extensively studied cytokines in the development of tissue fibrosis in response to irradiation and TGF-b1 signalling is an important modulator of the inflammatory response [5]
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