Abstract
Genetic polymorphisms define the cytokine production leading to susceptibility or resistance to diseases. We studied the cytokine polymorphism in the development of tegumentary leishmaniasis (TL). Genotyping of TNF-α, TGF-β1, IFN-γ, IL-6, and IL-10 were performed by polymerase chain reaction assay. G and C alleles of TGF- β1 (codon 25) were the most common in controls and patients, respectively. G/G was the most frequent genotype in controls, and G/C and C/C in patients. G/G genotype of codon 25 in TGF-β1 appeared to confer resistance, and G/C and C/C genotypes, susceptibility to TL in this population.
Highlights
Genetic polymorphisms define the cytokine production leading to susceptibility or resistance to diseases
We studied the cytokine polymorphism in the development of tegumentary leishmaniasis (TL)
Genotyping of TNF-α, TGF-β1, IFN-γ, IL-6, and IL-10 were performed by polymerase chain reaction assay
Summary
Genetic polymorphisms define the cytokine production leading to susceptibility or resistance to diseases. In this case-control and retrospective study, 2 groups were established based on a review of medical records, by focusing on the epidemiological data from diagnosed ATL patients who underwent treatment 2 years ago, and who live in endemic areas of the North and Northwest regions of the Southern state of Paraná, Brazil. Significant associations were not found between the IL-10 gene SNP and susceptibility in either patients or controls.
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