Abstract
POEM, also called nephronectin, is an extracellular matrix protein that is considered to play a critical role as an adhesion molecule in the development and functioning of various tissues, such as kidneys and bones. In the present study, we examined the molecular mechanism of POEM gene expression, and found that transforming growth factor-β (TGF-β) strongly inhibited POEM expression in the mouse osteoblastic cell line, MC3T3-E1. TGF-β-induced decrease of POEM expression occurred in both time- and dose-dependent manners through the activation of TGF-β receptor I and extracellular signal-regulated kinase/c-Jun N-terminal kinase pathways.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
