Abstract
There has been conflicting data as to the role of cholesterol ester transfer protein (CETP), which show that it is atherogenic or anti-atherogenic by the HDLcholesterol catabolism. Accordingly, further investigations are necessary as to the role of CETP. This study was conducted to determine the role of CETP for lipid metabolism in normotriglyceridemia. Methods Plasma lipid levels, apolipoprotein concentration and CETP activities were measured in 31 male and 19 female subjects (aged 30 to 80 years). Further more, their relationships to coronary heart disease (CHD) prevalence was analyzed. Patients with hepatic and thyroidal dysfunction and diabetes mellitus were excluded from this study. CETP activities were measured by the method of Katoh et al Results: A positive correlation between LDL-cholesterol and CETP activity (r=0.46, p<0.01) was found, but no correlation was found between HDL-cholesterol and CETP activity. There was no relationship between the incidence of CHD and CETP activity. Conclusion: It is suggested that CETP also plays an important role in the metabolism of LDL-cholesterol, in addition to in the transfer of HDLcholesterol. However, it remains unknown whether CETP is atherogenic or anti-atherogenic.
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