TG/HDL, Non-HDL, and TyG index as predictive parameters for CVDs in uncontrolled diabetic patients better than LDL-C and LDL/HDL ratio

Abstract

Type 2 diabetes is widely associated with dyslipidaemia in uncontrolled patients. Prediction parameters of cardiovascular diseases have controversial issue. Therefore, the aims of this study were to investigate i) the possibility of prediction of cardiovascular diseases (CVDs) from lipoprotein ratios (TG/HDL ratio, TC/HDL ratio) and/or non-HDL level ii) the role of TyG index in prediction of CVDs in uncontrolled DM. 107 participants were recruited in this study, 34 participants were DM (32%; control) and 73 participants were uncontrolled DM (68%). HbA1c, Fasting plasma glucose, lipid profile were measured. In this study the mean age of control DM group was (50.2±2.2), and (54.1±1.6) for uncontrolled group. Weight was higher in uncontrolled DM group. FPG and HbA1c were higher in uncontrolled group. Neither LDL-C nor LDL/HDL ratio showed a significant difference between controlled DM and Uncontrolled DM. TG/HDL was elevated in uncontrolled DM. non-HDL and TyG index were significantly increased in the uncontrolled group. We concluded that neither LDL-C nor LDL/HDL ratio have a predictive role for CVDs as proposed previously. TG/HDL ratio, non-HDL, and TyG index pointed out as a useful predictive parameters for CVDs in uncontrolled T2D.