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Abstract
Objective:Transcription factor activating protein 2 B (TFAP2 B) is a transcription factor that regulates many steps of embryogenesis, cell growth, apoptosis and recently oncogenesis and cancer progression. AP-1 is a transcription factor that is a downstream molecule of the MAPK signaling pathway. Juxtaposed with zinc finger gene 1 (JAZF1) is a recently detected transforming growth factor which has a role in carcinogenesis. Hence the present study aimed to assess those markers expression in tissues from patients with such cancer correlation their expression with clinic-pathological findings of the tumor and prognostic and follow-up findings of patients. Methods:We have collected tissue samples from papillary thyroid cancer patients and adjacent non-neoplastic tissues from 80 patients. We assessed the expression of TFAP2B, AP-1 and JAZF1 using immunohistochemistry. Results:Expression of TFAP2B was positively associated with lymph nodes metastases (p=0.003), distant metastases (p=0.002), recurrence of the tumor (p=0.002), unfavourable disease-free survival rate (p=0.003). AP-1 expression is positively associated with advanced stage (p=0.002), presence of extra-thyroid invasion (p=0.005), recurrence of the tumor (p=0.005), unfavorable disease-free survival rate (p=0.01). JAZF1 expression is negatively associated with huge tumor size (0.023), vascular invasion (p=0.007) and unfavorable overall survival rate (p=.030). Conclusion:High expression levels of TFAP2B and AP-1 and low expression levels of JAZF1 were associated with unfavourable pathological, prognostic parameters and dismal patient’s outcome.
Highlights
Thyroid cancer is considered the most prevalent endocrine system cancers that continued rising worldwide in the past decades (Xiao et al, 2019)
We included samples from 80 papillary thyroid cancers; 72 of them were diagnosed as having conventional papillary thyroid carcinoma, and 8 of them were diagnosed as having a follicular variant of papillary thyroid carcinoma and 80 samples from adjacent non-neoplastic thyroid tissue of the same patients (Table 1)
We found that TFAP2B expression was elevated in cells of papillary thyroid cancer in comparison to adjacent non-neoplastic thyroid tissues which are similar to results of Fu et al, (2019), in papillary thyroid cancer and Fu et al, (2014) in lung cancer
Summary
Thyroid cancer is considered the most prevalent endocrine system cancers that continued rising worldwide in the past decades (Xiao et al, 2019). Transcription factor activating protein 2 B (TFAP2 B) is a transcription factor that regulates many steps of embryogenesis, cell growth, apoptosis and recently oncogenesis and cancer progression (Xu et al, 2017, Fu et al, 2019). Juxtaposed with zinc finger gene 1 (JAZF1) is a recently detected transforming growth factor which has a role in carcinogenesis (Nakajima et al, 2004). As no previous studies have assessed the roles of TFAP2B, AP-1 and JAZF1 expression in patients with papillary carcinoma of the thyroid, we aimed to assess TFAP2B, AP-1 and JAZF1 expression in tissues from patients with such cancer correlation their expression with clinic-pathological findings of the tumor and prognostic and follow-up findings of patients
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