Abstract
Abnormality of transcription factors’ activity has been found in signal pathways of many cancers. The AP-2 family of transcription factors (TFAP2) is one of the most representative families with this characteristic. The family, consisting of five members (TFAP2A to TFAP2E), can activate or inhibit the target gene through signal transduction [1].
Highlights
By inducing ITPKA [9] and KRT16 [10], TFAP2A acts as an oncogene in lung adenocarcinoma and lung tumorigenesis, in coordination with TFAP2C [11]
(2) Only TFAP2A is associated with the prognosis of lung cancer (LC), whose expression level is negatively correlated with the overall survival rate of LC. (3) The mutation rate of TFAP2A and TFAP2C in LC are higher than that of TFAP2B
These findings suggest TFAP2A has prognostic value, which may improve survival and prognosis accuracy of LC patients
Summary
Researches have been focused on the association between TFAP2 family and lung cancer (LC). There are three significant findings in this study: (1) Compared with normal tissues, the expression of TFAP2A and TFAP2C increase in LC, while the expression of TFAP2B shows no significant difference. It is found in one research that the expression of TFAP2B is higher in lung cancer, which suggests poor prognosis [13]. It is reported in another study that expression of TFAP2B in the nucleus is related to poor survival [14].
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