Texture analysis of apparent diffusion coefficient (ADC) map for glioma grading: Analysis of whole tumoral and peri-tumoral tissue

Abstract

PurposeTo prospectively investigate the capabilities of texture analysis (TA) based on apparent diffusion coefficient (ADC) map of the entire tumor volume and the whole volume of peri-tumoral edema, in discriminating between high-grade glioma (HGG) and low-grade glioma (LGG). Materials and methodsA total of 33 patients with histopathological proven glioma were prospectively included. There were 20 men and 13 women with a mean age of 54.5±14.7 (standard deviation [SD]) years (range: 34–75years). TA parameters of whole tumor and peri-tumoral edema were extracted from the ADC map obtained with diffusion-weighted spin-echo echo-planar magnetic resonance imaging at 1.5–T. TA variables of HGG were compared to those of LGG. The optimum cut-off values of TA variables and their corresponding sensitivity, specificity and accuracy for differentiating between LGG and HGG were calculated using receiver operating characteristic curve analysis. ResultsMean and median tumoral ADC of HGG were significantly lower than those of LGG, at 1.23×10−3 mm2/s and 1.21×10−3 mm2/s cut-off values, yielding 70% sensitivity each (95% CI: 59–82% and 61–80%, respectively), 80% (95% CI: 79–98%) and 90% (95% CI: 82–97%) specificity, and 73% (95% CI: 66–91%) and 76% (95% CI: 72–90%) accuracy, respectively. Significant differences in tumoral and peri-tumoral kurtosis were found between HGG and LGG at 1.60 and 0.314 cut-off values yielding sensitivities of 74% (95% CI: 58–83%) and 70% (95% CI: 59–84%), specificities of 90% (95% CI: 80–95%) and 70% (95% CI: 64–83%) and accuracies of 79% (95% CI: 69–89%) and 70% (95% CI: 64–77%), respectively. ConclusionMeasurements of whole tumoral and peri-tumoral TA, based on ADC maps, provide useful information that helps distinguish between HGG and LGG.