Texture Analysis and Volumetry of Hippocampus and Medial Temporal Lobe in Patients with Alzheimer's Disease

Abstract

This study investigated the texture features and volumes of bilateral hippocampus and medial temporal lobe (MTL) in magnetic resonance imaging (MRI) in patients with Alzheimer's disease (AD). Texture features were extracted using gray level co-occurrence matrix (GLCM) in 29 elderly AD patients, 19 age-matched non-demented controls (EC) and 18 young healthy controls (YC). The correlation between texture features and corresponding volumes was analyzed. Significant differences were found in both HF and MTL between AD and EC group in both volumes (p