Abstract
A nanocomposite textile fiber electrode was functionalized with uricase for uric acid monitoring in chronic wound fluid. Uric acid is a metabolic product of purines which has a primary role in tissue healing by initiating the inflammatory process. Throughout the healing process, the uric acid levels are elevated in the wound fluids with relative concentrations correlating with wound chronicity. Though sensor devices implemented at point-of-care allows for rapid wound diagnostics, still there is no wearable technology for continuous monitoring. In this work, a three-dimensional high aspect ratio nanocomposite textile-based electrode was investigated. The unique structure of the electrode provided larger surface area for enzyme immobilization and an excellent platform for electron transfer from enzymatic reaction.
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