Abstract
Fine fibers of polyhydroxybutyrate (PHB), a biopolymer, were developed via a centrifugal spinning technique. The developed fibers have an average diameter of 1.8 µm. Texas sour orange juice (SOJ) was applied as a natural antibacterial agent and infiltrated within the fibrous membranes. The antibacterial activity against common Gram-positive and Gram-negative bacteria (Staphylococcus aureus and Escherichia coli, respectively) was evaluated as well as cell adhesion and viability. The PHB/SOJ scaffolds showed antibacterial activity of up to 152% and 71% against S. aureus and E. coli, respectively. The cell studies revealed a suitable environment for cell growth and cell attachment. The outcome of this study opens up new opportunities for fabrication of fibrous materials for biomedical applications having multifunctional properties while using natural agents.
Highlights
Wound management requires the use of wound dressings that could create suitable conditions to encourage the healing process, while providing external protection [1]
It can be clearly seen that the fiber mats have a clear ring around the mats can be clearly seen that the sour orange juice (SOJ)-coated PHB fiber mats have a clear ring around the mats (known depicting antibacterial while the control is uniformly as inhibition zone) depicting antibacterial activityactivity while the control samplesample is uniformly covered covered with bacteria
The results show larger inhibition zones against the Gram-positive bacteria (S. aureus); aureus); the antibacterial activity against
Summary
Wound management requires the use of wound dressings that could create suitable conditions to encourage the healing process, while providing external protection [1]. The study of nanofiber-based membranes for wound care applications has been intensified. Most of the reported studies have developed the nanofiber membranes using the electrospinning method, patented in 1902 by Cooley [3,4,5,6,7,8,9]. The Forcespinning® method patented in 2014 by Lozano and Sarkar [10], developed to scale up the fabrication of fine fiber membranes, has gained increasing attention in the biomedical field [11,12,13,14]. The preferred polymeric systems for wound care management have been PVP (polyvinyl pyrrolidone), PEO (polyethylene oxide), PLA (polylactic acid), PEG (polyethylene glycol), PVA (polyvinyl alcohol), PLGA (polylactide-co-glycolic acid), and PCL (polycaprolactone), to mention some [3,15]
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