Abstract
We investigated the anti-diabetic mechanisms of Teucrium cubense Jacq (Lamiaceae) assaying non-toxic concentrations of an aqueous extract of this plant (TE) on the 2-NBDglucose uptake [1] and adipogenesis [2] in 3T3-F442A murine and normal human subcutaneous adipocytes. In insulin-sensitive 3T3 adipocytes, TE stimulated the 2-NBDG uptake by 112% whereas in human adipocytes induced the 2-NBDG uptake by 54% respect to the 2-NBDG uptake stimulated by insulin. TE also induced 2-NBDG uptake in insulin-resistant murine and human adipocytes by 69% and 31% respectively. TE (70µg/mL) added to murine adipogenic medium increased 3T3 adipogenesis by 167% whereas added to human adipogenic medium induced human adipogenesis by 138%. Under non adipogenic conditions, TE only marginally increased adipogenesis by 13% in 3T3 preadipocytes and by 9% in human preadipose cells, suggesting that this preparation lacks of pro-adipogenic effects. Our results suggest that Teucrium cubense exerts its anti-diabetic effects stimulating glucose uptake in both insulin-sensitive and insulin-resistant murine and human adipocytes without affecting triglyceride accumulation. Acknowledgements: RZB and AJAC were endowed with graduate fellowships from CONACYT (211445 and 210841, respectively). AJAC also received special support from IPICYT (SA-157/2008).
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