Abstract
The C fiber compound action potentials (C-CAPs) were studied for their properties with the vaseline gap method from the isolated bullfrog sciatic nerve. Two components (the fast and the slow C-CAPs) were found to be Na + dependent and tetrodotoxin-resistant. The conduction velocities of the fast and the slow C-CAPs were 0.61±0.06 m/s ( n=13) and 0.42±0.05 m/s ( n=8), respectively; their time constants were 11.4±1.7 ms and 16.3±1.7 ms, respectively, with both parameters being significantly different at P<0.01. The slow C-CAP had about 1.3 times higher threshold than that of the fast C-CAP, with a significant difference ( P<0.01). They showed differential sensitivity to lidocaine and Cd 2+. Capsaicin reduced the amplitudes of both fast and slow C-CAPs, but not abolished. These findings indicate that C fibers have at least two subtypes with different properties.
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