Abstract
The rapid development of multidrug-resistant strains and nosocomial P. aeruginosa infections pose a growing threat in the clinical setting. Tetraspanin CD9 peptides has demonstrated the antimicrobial activity against various gram-positive and -negative bacteria. Recently, CD9 peptides have shown anti-adhesion properties against P. aeruginosa isolates. In this study, we investigated the effect of CD9 peptides on the membrane of P. aeruginosa by transmission electron microscopy (TEM). The result shows the CD9 peptides cause disruption of the membrane of P. aeruginosa. In addition to the established antibacterial properties, this work reveals that tetraspanin CD9 peptides, a membrane-disrupting drug, could possibly be used as an additional treatment approach against P. aeruginosa. Future research should incorporate confocal microscopy to locate the bacterial matrix components and distinguish between living and dead P. aeruginosa upon the treatment with CD9 peptides.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Asia Pacific Journal of Molecular Biology and Biotechnology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
