Abstract
Tetramethylenedisulfotetramine (TETS, tetramine) is a toxic organic compound that is used as an effective rodenticide. However, this neurotoxin is not only toxic to rodents, it also causes poisoning in humans. Due to its high level of toxicity for humans, the use of TETS as a rodenticide has been banned and its production has been discontinued. Despite this, human poisoning by this substance is unfortunately still very common. The largest number of poisonings are reported in China, but in the United States, dozens of poisonings still happen annually. TETS is one of the most hazardous pesticides and also a possible chemical warfare agent with no known antidote. In this article, we aim to summarize the biochemical and toxicological data of TETS and hope to cast some light on the toxicological risk to human health.
Highlights
Tetramethylenedisulfotetramine (TETS) is a highly toxic convulsant and a potent antagonist of γ-aminobutyric acid (GABA), leading to excitation
Following a recent case report confirming the presence of TETS in the United States, and taking into consideration consideration the the toxicity toxicity of of this this compound, compound, the the absence absence of of an an antidote, antidote, and and the potential potential of its utilization as asan anagent agentofofintentional intentional mass poisoning, educational efforts undertaken in mass poisoning, educational efforts havehave been been undertaken in many many countries to inform the public about this potentially lethal rodenticide
A gas chromatography (GC) method for TETS determination has been conducted by Wu et al [41], an average recovery of 89.8% and a detection limit of 1.00 ng was achieved for TETS
Summary
Tetramethylenedisulfotetramine (TETS) is a highly toxic convulsant and a potent antagonist of γ-aminobutyric acid (GABA), leading to excitation. Following a recent case report confirming the presence of TETS in the United States, and taking into consideration consideration the the toxicity toxicity of of this this compound, compound, the the absence absence of of an an antidote, antidote, and and the potential potential of its utilization as asan anagent agentofofintentional intentional mass poisoning, educational efforts undertaken in mass poisoning, educational efforts havehave been been undertaken in many many countries to inform the public about this potentially lethal rodenticide [9].short.
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