Abstract
Canine mammary tumors (CMT) are very common in female dogs, representing approximately 50% of all tumors in this species, but are highly uncommon in male dogs and are primarily related to hyperestrogenism. There is considerable scientific interest in the possible role of environmental contaminants in the etiology of mammary tumors, specifically in relation to synthetic chemical substances released into the environment to which living beings are either directly or indirectly exposed. In this study, the presence of pyrethroid insecticide was observed in adipose tissue adjacent to canine mammary tumors. High Precision Liquid Chromatography—HPLC was adapted to detect and identify environmental contaminants in adipose tissue adjacent to malignant mammary tumor in one male dog, Akita, 12 years old. After surgery, the mass was carefully examined for malignant neoplastic lesions. Five grams of adipose tissue adjacent to the tumor was collected to detect environmental contaminants. The pyrethroid was identified as tetramethrin, at 0.20 μg/g. This is the first report in which the environmental contaminant level was detectable in adipose tissue of this male dog with a malignant mammary tumor, by HPLC. Results suggest the possible involvement of pyrethroid in the canine mammary tumor carcinogenesis since this animal did not present any other tumor that could cause hyperestrogenism.
Highlights
Canine mammary tumors (CMT) are very common in female dogs, representing approximately 50% of all canine tumors [1,2,3] and are highly uncommon in male dogs [4,5]
The present work aims to report one case of environmental contamination in the adipose tissue adjacent to a mammary tumor located in the right cranial thoracic, caudal thoracic and cranial abdominal breasts in a male 12-year-old Akita dog weighing 22 kg
Fragments of the tumor were collected for histopathology (Figure 1) whereas peri-tumoral fat was removed for subsequent analysis of the presence of pyrethroid contamination by the technique of High Precision Liquid Chromatography (HPLC) following the method of Bissacot and Vassilieff (1997) [17] at the CEATOX laboratory—UNESP—Botucatu
Summary
Canine mammary tumors (CMT) are very common in female dogs, representing approximately 50% of all canine tumors [1,2,3] and are highly uncommon in male dogs [4,5]. Tance of CMT to researchers, given its particular similarity to human breast cancer, making the dog, an excellent model for studying this disease, given the similarity of the epidemiological, clinical, biological and, apparently, genetic characteristics between the human and canine forms of the affliction. For all of these reasons, and because the number of men with breast neoplasia increases each year, the study of CMT in male dogs has become extremely important. The present work aims to report one case of environmental contamination in the adipose tissue adjacent to a mammary tumor located in the right cranial thoracic, caudal thoracic and cranial abdominal breasts in a male 12-year-old Akita dog weighing 22 kg
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