Abstract
A previously unreported association of tetralogy of Fallot and total anomalous pulmonary venous drainage is described in two infants. The initial clinical manifestation was tetralogy, and both patients had systemic-pulmonary shunt surgery to increase the pulmonary blood flow. Postoperatively, one infant died of massive pulmonary edema, and at postmortem examination total anomalous pulmonary venous drainage below the diaphragm was found. The other patient had the association of tetralogy with anomalous pulmonary venous drainage into the coronary sinus diagnosed by cardiac catheterization. Following shunt surgery, prolonged continuous positive airway pressure was necessary to adequately ventilate the lungs, presumably the result of pulmonary venous congestion and low pulmonary compliance. The infant eventually died from tracheostomy complications. The diagnosis, clinical course, surgical implications and pathology of this association are discussed. A previously unreported association of tetralogy of Fallot and total anomalous pulmonary venous drainage is described in two infants. The initial clinical manifestation was tetralogy, and both patients had systemic-pulmonary shunt surgery to increase the pulmonary blood flow. Postoperatively, one infant died of massive pulmonary edema, and at postmortem examination total anomalous pulmonary venous drainage below the diaphragm was found. The other patient had the association of tetralogy with anomalous pulmonary venous drainage into the coronary sinus diagnosed by cardiac catheterization. Following shunt surgery, prolonged continuous positive airway pressure was necessary to adequately ventilate the lungs, presumably the result of pulmonary venous congestion and low pulmonary compliance. The infant eventually died from tracheostomy complications. The diagnosis, clinical course, surgical implications and pathology of this association are discussed. Adverse Drug ReactionsCHESTVol. 64Issue 3PreviewIntensive monitoring of adverse drug reactions in hospitals has pointed to a problem of great magnitude.1-3 Up to 5 percent of all patients were suffering from drug reactions when admitted. Fifteen to 30 percent of all hospitalized patients developed drug reactions before discharge. In the United States, approximately one-seventh of hospital days are devoted to the treatment of drug reactions at an estimated cost of 3 billion dollars annually.4 Full-Text PDF
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