Tetrakis(dimethylamino)ethylene (TDAE) as a useful reductant of some chlorodifluoromethylated ketones. A new approach for the synthesis of α,α-difluoroketone derivatives

Abstract

Tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective reductant of chlorodifluoromethylated ketones 1–3. The generated α,α-difluoroacetyl anion was trapped with several aldehydes 4–7, under mild conditions, to give the corresponding 2,2-difluoro-3-hydroxy ketone derivatives 8–13, in moderate yields.