Abstract
We investigated proinflammatory cytokine TNFα production inhibitors in order to develop novel anti-inflammatory agents. According to the results, we found that 17, a pyrrole derivative possessing a tetrahydropyridine group at the β-position, showed potent inhibitory activity in vitro (inhibition of lipopolysaccharide (LPS) induced TNFα production in human whole blood, IC 50 = 1.86 μM) and in vivo (inhibition of LPS induced TNFα production in mice, ID 50 = 5.98 mg/kg).
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