Abstract
Hyperlipidemia (HLP) is a lipid metabolism disorder that can induce a series of cardiovascular and cerebrovascular diseases, such as atherosclerosis, myocardial infarction, coronary heart disease, and stroke, which seriously threaten human health. Tetrahydropalmatine (THP) is a component of the plant Rhizoma corydalis and has been shown to exert hepatoprotective and anti-inflammatory effects in HLP. However, whether THP regulates lipid peroxidation in hyperlipidemia, endoplasmic reticulum (ER) stress and inflammasome activation and even the underlying protective mechanism against HLP remain unclear. An animal model of HLP was established by feeding a high-fat diet to golden hamsters. Our results showed that THP reduced the body weight and adipose index; decreased the serum content of ALT, AST, TC, TG, and LDL-C; decreased the free fatty acid hepatic lipid content (liver index, TC, TG, and free fatty acid); inhibited oxidative stress and lipid peroxidation; extenuated hepatic steatosis; and inhibited ER stress and inflammasome activation in high-fat diet-fed golden hamsters. In addition, for the first time, the potential mechanism by which THP protects against HLP through the TLR4-NF-κB signaling pathway was demonstrated. In conclusion, these data indicate that THP attenuates HLP through a variety of effects, including antioxidative stress, anti-ER stress, and anti-inflammatory effects. In addition, THP also inhibited the TLR4-NF-κB signaling pathway in golden hamsters.
Highlights
Hyperlipidemia (HLP) is a disorder of abnormal lipid metabolism that manifests as one or several lipid disorders in plasma, including elevated plasma cholesterol, triacylglycerol, and low-density lipoprotein cholesterol; increased fat accumulation; or reduced high-density lipoprotein cholesterol levels [1]
The model used was high-fat diet-induced HLP in golden hamsters. e present study was carried out to study the critical role of THP in lipid peroxidation, endoplasmic reticulum (ER) stress, and inflammasome activation involved in liver injury in high-fat diet-induced HLP and to unveil the possible mechanisms
After continuous administration for 6 weeks, the weight and adipose index of hamsters in the M group were significantly higher than those in the NC group (Figures 1(a) and 1(b)). Compared with those in the M group, the weight and adipose index of hamsters in the positive control group (PC), HD, and MD groups were significantly decreased, but there was no significant difference in the LD group (Figures 1(a) and 1(b)), indicating that THP has an antiobesity effect on fat formation induced by a high-fat diet
Summary
Hyperlipidemia (HLP) is a disorder of abnormal lipid metabolism that manifests as one or several lipid disorders in plasma, including elevated plasma cholesterol, triacylglycerol, and low-density lipoprotein cholesterol; increased fat accumulation; or reduced high-density lipoprotein cholesterol levels [1]. E drugs used to treat HLP mainly include statins, fibrates, cholic acid chelating agents, and niacin [6,7,8]. These hypolipidemic drugs can effectively and rapidly reduce blood lipids, their long-term use can cause toxicity and side effects, such as abdominal distension, diarrhea, muscle weakness, muscle dissolution, and other adverse reactions [9]. E present study was carried out to study the critical role of THP in lipid peroxidation, ER stress, and inflammasome activation involved in liver injury in high-fat diet-induced HLP and to unveil the possible mechanisms The model used was high-fat diet-induced HLP in golden hamsters. e present study was carried out to study the critical role of THP in lipid peroxidation, ER stress, and inflammasome activation involved in liver injury in high-fat diet-induced HLP and to unveil the possible mechanisms
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
