Abstract
The paper describes the preparation, characterisation, and testing of tetracycline loaded collagen-carboxymethylcellulose/hydroxyapatite ternary composite materials. The synthesis of this drug delivery system consists in two steps: the first step is the mineralization of collagen-carboxymethylcellulose gel while the second step corresponds to the loading of the ternary composite material with tetracycline. The obtained DDS is characterised by physicochemical, morphological, and release behaviour by using FTIR spectroscopy and microscopy, scanning electron microscopy, and UV-VIS spectroscopy. Based on the release study, it can be assumed that tetracycline is released in a prolonged way, assuring at least 6 days of antiseptic properties.
Highlights
Collagen (COLL) and hydroxyapatite (HA) are the main components of the bone [1]
The paper describes the preparation, characterisation, and testing of tetracycline loaded collagen-carboxymethylcellulose/ hydroxyapatite ternary composite materials. The synthesis of this drug delivery system consists in two steps: the first step is the mineralization of collagen-carboxymethylcellulose gel while the second step corresponds to the loading of the ternary composite material with tetracycline
Scanning electron microscopy is a useful tool for characterizing materials, the morphology of the materials being essential both for bone grafts and for drug delivery systems
Summary
Collagen (COLL) and hydroxyapatite (HA) are the main components of the bone [1] This is why many materials designed for bone grafting and repair are based on collagen, hydroxyapatite, or composite materials containing the aforementioned components. The performances of these synthesized materials are strongly dependent on the composition and processing induced morphology [1,2,3,4]. The collagen-carboxymethylcellulose/hydroxyapatite (COLL-CMC/HA) was previously obtained in our group and seems to be proper material for bone grafting and repair [5]. COLL-CMC/HA composite material containing both fibres (CMC) and particles (HA) as reinforcing agent is a true hybrid material, expecting superior mechanical properties compared to COLL/HA composite materials
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