Abstract
Abstract A continuing phytochemical study on the semi-mangrove plant Hibiscus tiliaceus yielded two new tetracyclic triterpenoids (3 β ,24 S )-19(10→9)- abeo -8 α ,9 β ,10 α -eupha-5,25(26)-dien-3,24-diol (tiliacol A, 1 ), and (3 β ,23 Z )-19(10→9)- abeo -8 α ,9 β ,10 α -tircalla-5,23-dien-3,25-diol (tiliacol B, 3 ), together with one known analog ( 2 ). Their structures were elucidated on the basis of extensive spectral analyses (MS, IR, 1D NMR and 2D NMR) and comparison with literature compounds. Compound 2 showed potent cytotoxicity against both P388 and HeLa cells with IC 50 values of 11.2 μmol/L and 11.5 μmol/L, respectively.
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