Tetanus and diphtheria antibodies and response to a booster dose in Brazilian HIV-1-infected women

Abstract

Tetanus and diphtheria (Td) antibodies were studied in HIV-1-infected women during puerperium. HIV group ( n=61) was compared with Control group ( n=101). Twenty-one women from HIV and 13 from Control group who had antibody levels lower than 0.1 IU/mL received a booster with Td vaccine. Antibodies were assessed by double antigen ELISA. Mean tetanus and diphtheria antibody levels from HIV group were lower than those from Control group. Multiple linear regression analysis showed that tetanus and diphtheria antibody levels were decreased by HIV-1-infection, and that was independent of the reduction due to the time interval between last booster and antibody assessment. After a booster dose, both groups had an increase in mean tetanus and diphtheria antibody levels, but in Control group the levels were higher than in HIV group.