TESTS IN HAMSTERS FOR ONCOGENIC QUALITY OF ORDINARY VIRUSES INCLUDING ADENOVIRUS TYPE 7.

Abstract

SummaryStudies were conducted to measure the in vivo oncogenic potential of a variety of “ordinary” viruses. Adenovirus 1, 2, 7, 12 and 18, influenza A2, parainfluenza 1, 2 and 3, respiratory syncytial, mumps, measles, rhinovirus 11, 23 and 30, poliovirus 3, salivary gland virus, varicella, pneumonia virus of mice, Rous sarcoma, visceral lym-phomatosis and resistance-inducing factor (avian leucosis) viruses were tested for ability to induce tumors in hamsters inoculated when newborn, A majority of animals given adenovirus types 12 or 18 developed tumors. Additionally, a portion of animals which received type 7 adenovirus developed sarcomas. Evidence is presented for the significance of type 7 adenovirus in tumor development. Two animals given Bryan's Rous sarcoma virus also developed sarcomas. None of the animals which received any of the other viruses presented significant evidence for induction of malignancy. Studies of additional viruses are in progress.Addendum: Since the time the present manuscript w...