Abstract
SummaryVaginal douches of 4% methyl bis (β-chloroechyl) amine hydrochloride produced 53 lethals in 5488 egg and sperm X chromosomes tested while only 13 lethals were observed in the 6271 sperm or egg X chromosomes tested after treatments with formaldehyde, copper sulfate, 2,4-dinitrophenol, hydrazine hydrate and trypsin. The practicality of the vaginal douche technic for the induction of mutations with N mustard in both sperm and eggs, suggested from previous experiments, is confirmed in that 30 lethals occurred in the 2951 sperm tested and 23 in the 2537 eggs tested. The number of sperm X chromosome lethals seems to be considerably higher in F1 females resulting from single copulations within a two hour period from the time of injection (23 lethals in 1416 tests) than it is in females from copulations after this interval (7 lethals in 1535 tests); the mutation rate for the egg X chromosome under these conditions remains apparently unaffected (9/1083 and 14/1454, respectively). Whereas the 30 sperm lethal...
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